Results of the survey on determination of the mean activity levels of alanine aminotransferase and aspartate aminotransferase / Монголын Анагаах Ухаан

ABSTRACT

The serum activity levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) are important biochemical indicators of changes in the liver and coronary system function. The correct determination of changes in the activity levels of the transferases is essential for differential diagnosis and appropriate treatment of the diseases. Goal The aim of this study was to determine the mean activity levels of ALT and AST of the Mongolian population. Materials and Methods: Serum was separated from morning blood samples collected from 1732 individuals 15-64 years of age (706 males, 1026 females) from 21 aimags and Ulaanbaatar city, and stored at -30°C until analysis. Activity levels of alanine aminotransferase and aspartate aminotransferase were determined using photometric system. Results: The overall mean serum activity level of AST was 25.52 U/L and of ALT was 22.60 U/L. No statistically significant differences were observed between the surveyed from Ulaanbaatar and from rural area as well as between sexes (p>0.05 for both ALT and AST). When the survey participants were divided into five age groups (15-24 years, 25-34 years, 35-44 years, 45-54 years and 55-64 years of age) and their mean activity levels of AST and ALT were compared, it was observed that the activity of both enzymes increased with age (p<0.05)