Serum total testosterone, follicle stimulating hormone and luteinizing hormone in aging males / Монголын Анагаах Ухаан

ABSTRACT

Background: Most of the country has been increasing the life expectancy and to relate aging man also have been increasing among population. Affected by human aging internal major factor is the change of Hypothalamus-Pituitary-Gonadal axis. Thus, we have proposed to study to change of regulating gonadothropin-gonadal axe in aging males. Goal To study the serum total testosterone, gonadothropin hormones level in aging males and its correlation with aging. Materials and Methods: In this study were involved 149 healthy Mongolian men aged above 35 years. Subjects were randomly selected. Blood samples were collected in the morning 8.30-10.00 AM, 4ml blood from vein vassal. The serum concentration of total testosterone, luteinizing hormone, follicle stimulating hormone was assayed by ELISA. Results: Total participant’s average age was 57.8±13.4 years. Average level of testosterone was 4.95±2.08ng/ml and there is no significant correlation with aging (r=0.084, p=0.331). But average level of FSH was 9.12±9.09 IU/L and FSH has increased with aging. Between age and FSH was found moderate and direct correlation (r=0.425, p0.05) correlation of LH (β=0.170) with Testosterone, which was stronger than FSH (β=0.156).