Retinal toxicity of moxifloxacin injected intravitreally into rabbit eyes: A histological study
Philippine Journal of Ophthalmology
;
: 17-19, 2005.
Article
in English
| WPRIM
| ID: wpr-632395
ABSTRACT
OBJECTIVE:
To investigate the retinal toxicity of different doses of moxifloxacin after intravitreal injection into rabbit eyes.METHODS:
Eight male rabbits were divided into four groups; 2 rabbits each were injected intravitreally with moxifloxacin 48 ug, 240 ug, 480 ug, and normal saline solution. Ocular toxicity was assessed at day 3 and day 7 by slit-lamp biomicroscopy, ophthalmoscopy, and histology.RESULTS:
All eyes showed no abnormalities on histologic evaluation. No relevant complications were found during slit-lamp biomicroscopy and indirect ophthalmoscopy.CONCLUSION:
Intravitreal injection of 480 ug or less of moxifloxacin did not produce retinal toxicity histologically in rabbit eyes.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Endophthalmitis
/
Intravitreal Injections
/
Moxifloxacin
/
Animals
Language:
English
Journal:
Philippine Journal of Ophthalmology
Year:
2005
Type:
Article
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