A randomized, double-blind, placebo-controlled study on the safety and efficacy of 0.025% capsaicin (Capsicum annuum var. longum) cream against 1% hydrocortisone cream as an anti-inflammatory and anti-pruritic preparation for mosquito bites
Journal of the Philippine Dermatological Society
;
: 26-35, 2011.
Article
in English
| WPRIM
| ID: wpr-633058
ABSTRACT
BACKGROUND:
Mosquito bite is a common dermatological complaint with various treatments but with no gold standard treatment regimen.OBJECTIVE:
To compare the safety and efficacy of 0.025% capsaicin cream against 1% hydrocortisone cream and placebo as anti-inflammatory and anti-pruritic preparation for mosquito bites.METHODS:
Seventy-five volunteers were enrolled in the placebo-controlled trial and randomized into three treatment groups. They were exposed to laboratory-reared mosquitoes to incur bites and to apply the designated cream. Anti-inflammatory and anti-pruritic effects were determined by mean lesion size, physician's global assessment, pruritus intensity score and 100mm visual analog scale.RESULTS:
The mean lesion size and physician's global assessment, pruritus intensity score and visual analog scale showed no significant difference between 0.025% capsaicin and 1% hydrocortisone and they were both found to be superior to placebo (p-valueCONCLUSION:
0.025% capsaicin is comparable to 1% hydrocortisone as an anti-inflammatory and anti-pruritic preparation for mosquito bites.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pruritus
/
Volunteers
/
Cortisone
/
Hydrocortisone
/
Capsaicin
/
Analysis of Variance
/
Visual Analog Scale
/
Insect Bites and Stings
/
Animals
/
Culicidae
Type of study:
Controlled clinical trial
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Journal of the Philippine Dermatological Society
Year:
2011
Type:
Article
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