Treatment outcomes with the use of a stepwise insulin combinations algorithm among type 2 diabetic patients
Philippine Journal of Internal Medicine
;
: 1-7, 2016.
Article
in English
| WPRIM
| ID: wpr-633363
ABSTRACT
INTRODUCTION:
In the management of type 2 diabetes, insulin is often started late, when there is failure to achieve good control on maximum oral agents. Clinical inertia to insulin initiation and intensification is widely prevalent in our local setting resulting in poor control of diabetes. This study looked into a stepwise insulin combinations treatment algorithm used in an Endocrinology referral clinic at the University of Santo Tomas Hospital (USTH). It aimed to demonstrate the clinical course of the patients , determine the degree of HbA1c reduction, and show the associated extent of hypoglycemia and weight gain.METHODS:
This is a retrospective chart review of 104 patients that used the following stepwise treatment Oral regimen; Regimen A basal+oral; Regimen B basal+premeal bolus TID±oral; Regimen C premixed aspart 70/30 or lispro 75/25 TID or BID with prelunch bolus, ± oral; Regimen D premixed 70/30 BID+premeal bolus TID ± oral; Regimen E premixed 70/30 BI +premeal bolus TID+basal ±oral. All received automatic snacking two hours after main meals to prevent hypoglycemia. Patients were educated on proper diet and exercise. Data was analyzed using paired t-test, frequencies and percentages.RESULTS:
Most ended on the intensive insulin regimens D 57(55%), and E 18 (17%). Significant HbA1c reduction was demonstrated as follows Regimen A (n=8)1.376±0.919 (p=0.000), Regimen B (n=18)2.320±2.177 (p=0.000), Regimen D (n=57)2.197±2.158 (p=0.000), Regimen E (n=18)2.684±1.689 (p =0.000). Overall mean weight gain was 1.070 ± 11.435 kg (p=0.335). Ten, nonsevere hypoglycemia events were reported.CONCLUSION:
The use of this stepwise insulin combinations treatment algorithm exerted significant HbA1c reduction, with minimal events of hypoglycemia, and statistically insignificant weight gain. Hence, this is a feasible tool that may be used as a guide for intensification of insulin treatment.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Algorithms
/
Weight Gain
/
Antineoplastic Combined Chemotherapy Protocols
/
Diabetes Mellitus, Type 2
/
Diet
/
Insulin Lispro
/
Hypoglycemia
/
Insulin
Type of study:
Prognostic study
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
English
Journal:
Philippine Journal of Internal Medicine
Year:
2016
Type:
Article
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