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Distribution of Adenoviral Vector in Brain after Intravenous Administration
Journal of Korean Medical Science ; : 108-111, 2003.
Article in English | WPRIM | ID: wpr-63344
ABSTRACT
The delivery of transgenes to the central nervous system (CNS) can be a valuable tool to treat CNS diseases. Various systems for the delivery to the CNS have been developed; vascular delivery of viral vectors being most recent. Here, we investigated gene transfer to the CNS by intravenous injection of recombinant adenoviral vectors, containing green fluorescence protein (GFP) as a reporter gene. Expression of GFP was first observed 6 days after the gene transfer, peaked at 14 days, and almost diminished after 28 days. The observed expression of GFP in the CNS was highly localized to hippocampal CA regions of cerebral neocortex, inferior colliculus of midbrain, and granular cell and Purkinje cell layers of cerebellum. It is concluded that intravenous delivery of adenoviral vectors can be used for gene delivery to the CNS, and hence the technique could be beneficial to gene therapy.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Purkinje Cells / Tail / Recombinant Fusion Proteins / Brain / Inferior Colliculi / Comparative Study / Blood-Brain Barrier / Tissue Distribution / Cerebellum / Adenoviruses, Human Limits: Animals Language: English Journal: Journal of Korean Medical Science Year: 2003 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Purkinje Cells / Tail / Recombinant Fusion Proteins / Brain / Inferior Colliculi / Comparative Study / Blood-Brain Barrier / Tissue Distribution / Cerebellum / Adenoviruses, Human Limits: Animals Language: English Journal: Journal of Korean Medical Science Year: 2003 Type: Article