Clinical profile of pertussis among pediatric patients admitted at the Philippine General Hospital
Pediatric Infectious Disease Society of the Philippines Journal
;
: 21-27, 2015.
Article
in English
| WPRIM
| ID: wpr-633506
ABSTRACT
@#<p style="text-align justify;"><strong>OBJECTIVE:
</strong> The aim of this research was to describe the epidemiologic, clinical laboratory and microbiologic characteristics, complications and outcome of pertussis among pediatric patients at the Philippine General Hospital.<br /><strong>METHODS:
</strong> A retrospective chart review was performed which included pediatric patients with final diagnosis of pertussis, both clinical and laboratory -confirmed admitted from December 2012 to August 2013 at the Philippine General Hospital. <br /><strong>RESULTS:
</strong> This chart review included 28 pertussis patients highest in those aged 1-3 months (86%), females (57%) and from region 4A (57%). 26 (93%) had exposure to household members with respiratory symptoms and unknown pertussis vaccination status. Of those patients who were eligible for vaccination, only 24% received age-appropriate DPT vaccination.<br />Onset of illness varied from 3-56 days; majority 9/L, range 14.7-111.5x109/L;), lymphocytic predominance (mean lymphocyte 0.47, range 0.20-0.72;) and thrombocytosis (mean platelet count 567x109/L, range 269-823x109/L;). 28% were culture positive for B. pertussis, while 86% tested positive for PCR.<br />The most common complications were pneumonia requiring mechanical ventilation (64%), ARDS (28%), seizures (21%), nosocomial pneumonia (11%) and myocarditis (11%). The average length of hospital stay was 7.4 days with 13 deaths or 46% case fatality rate. Deaths were attributed to respiratory failure due to progressive pneumonia and ARDS. Other contributing causes were arrhythmia, MODS, and septic shock.<br /><strong>CONCLUSION:
</strong> Susceptible young infants acquire pertussis from household contacts with respiratory symptoms. Paroxysmal cough and cyanosis are common clinical features, with leukocytosis, lymphocytosis and thrombocytosis. High case fatality rate for pertussis was noted among these patients.<br /><br /></p>
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Index:
WPRIM (Western Pacific)
Main subject:
Arrhythmias, Cardiac
/
Respiratory Insufficiency
/
Thrombocytosis
/
Bordetella pertussis
/
Whooping Cough
/
Cross Infection
/
Leukocytosis
/
Lymphocytosis
Limits:
Female
/
Humans
/
Infant
/
Male
Language:
English
Journal:
Pediatric Infectious Disease Society of the Philippines Journal
Year:
2015
Type:
Article
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