Protective effect of GSH on PD model induced by 6-OHDA in vitro / 华中科技大学学报(医学)(英德文版)
Journal of Huazhong University of Science and Technology (Medical Sciences)
;
(6): 355-8, 2002.
Article
in English
| WPRIM
| ID: wpr-634113
ABSTRACT
To study the effects of 6-hydroxydopamine (6-OHDA) and reduced glutathione (GSH) on the nigral dopaminergic neurons in brain slices in vitro, immolunohistochemical technique was used to observe the changes of TH-stained neurons, including cell bodies and the dendrites, in the substantia nigra (SN) of midbrain slices of rats after incubation for 1 h in the presence of GSH 15 min before and during the period of incubation with 6-OHDA. The results showed that cell bodies remained intact but dendrites were fragmented and truncated after treatment with 6-OHDA. The antioxidant GSH alone did not significantly affect the dendrites of SN neurons but prevented 6-O-HDA-induced damage of dendrites. It was concluded that glutathione may prevent 6-OHDA-induced dopaminergic neurodegeneration and play a protective role in dopaminergic neurons.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Parkinson Disease, Secondary
/
Tyrosine 3-Monooxygenase
/
Substantia Nigra
/
Random Allocation
/
Oxidopamine
/
Rats, Sprague-Dawley
/
Glutathione
/
Neurons
Type of study:
Controlled clinical trial
Language:
English
Journal:
Journal of Huazhong University of Science and Technology (Medical Sciences)
Year:
2002
Type:
Article
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