ANP T2238C, C-664G gene polymorphism and coronary heart diseasein chinese population / 华中科技大学学报（医学）（英德文版）

ABSTRACT

The association between atrial natriuretic peptide (ANP) polymorphism and coronary heart disease (CHD) was studied in Chinese population. The genotypes of ANP T2238C and ANP C-664G were detected by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) methods in 158 consecutive CHD patients and 165 controls. It was found that the distribution of A2A2 genotype in CHD group was significantly higher than that in control group (P0.05). The results suggest that A2A2 T2238C genotype could be one of the risk factors for CHD (P<0.05, OR 1.80, 95 % CI 1.03-3.15).