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Disposition and tissue distribution of ML12 in rats / 华中科技大学学报(医学)(英德文版)
Article in En | WPRIM | ID: wpr-634586
Responsible library: WPRO
ABSTRACT
To investigate the disposition and tissue distribution of ML12 after intravenous (iv) administration in rats, the compound in plasma or in tissue was extracted into ethyl acetate under basic condition and was determined by HPLC after extracted by dilute sulfuric acid. Excitation wavelength and emission wavelength of fluorescence detection were 278 nm and 307 nm, respectively. The data were processed with the software 3P97 to calculate the main pharmaceutical parameters of ML12. At dose of 5 and 10 mg/kg, the elimination of the drug from plasma was found to be kinetically linear, but when the dosage was 20 mg/kg, a non-linear feature was observed. The highest level of ML12 was found in the kidney. Distribution of ML12 after iv administration was extensive and the concentration-time profile was found to be fitted to an open two-compartment model.
Subject(s)
Full text: 1 Index: WPRIM Main subject: Spectrometry, Fluorescence / Sulfuric Acids / Pharmaceutical Preparations / Kinetics / Biological Availability / Tissue Distribution / Chromatography, High Pressure Liquid / Rats, Sprague-Dawley / Antihypertensive Agents Language: En Journal: J. huazhong univ. sci. tech. med. sci Year: 2008 Type: Article
Full text: 1 Index: WPRIM Main subject: Spectrometry, Fluorescence / Sulfuric Acids / Pharmaceutical Preparations / Kinetics / Biological Availability / Tissue Distribution / Chromatography, High Pressure Liquid / Rats, Sprague-Dawley / Antihypertensive Agents Language: En Journal: J. huazhong univ. sci. tech. med. sci Year: 2008 Type: Article