Method for determination of the effective dose ED50
Pharmaceutical Journal
;
: 2-4, 2004.
Article
in Vietnamese
| WPRIM
| ID: wpr-6346
ABSTRACT
There are 4 principle of determination of ED50, the dose effective on 50% of experimental animals. Animals had been distributed into various analogue for diverse doses of studied substance. The evaluation will be carried according to the principle of "yes/no". For 1st example To determine ED50 concerning the anti-fibrillation effect of venous infective propranolol on BaCl2 included heart fibrillation experimental model of rabbit.Result showed an efficacious dose of ED50 = 1,97mg/kg. For 2nd example to determine ED50 concerning the hypoglycemic effect of glibenclamid on alloxan included hyperglycemic experimental model on white rat. Result showed on efficacious dose of ED50 = 6,02mg/kg
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmaceutical Preparations
/
Animal Experimentation
/
Diagnosis
Type of study:
Diagnostic study
Language:
Vietnamese
Journal:
Pharmaceutical Journal
Year:
2004
Type:
Article
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