Selective expression of progesterone receptor in malignant melanoma was inversely correlated with PCNA / 华中科技大学学报(医学)(英德文版)
Journal of Huazhong University of Science and Technology (Medical Sciences)
;
(6): 216-8, 2008.
Article
in English
| WPRIM
| ID: wpr-634650
ABSTRACT
To investigate the role of progesterone receptor (PR) expression in malignant melanoma (MM), PR and proliferative cell nuclear antigen (PCNA) expression were immunohistochemistrically evaluated in a series of 35 specimens of MM, and the correlation between the immunohistochemistrical findings and clinicopathological data was also analyzed. PR expression was detected in 25.7% (9/35) of the patients with MM. No PR expression was observed in nevi. PR expression was inversely correlated with PCNA expression (r=-0.353, P=0.026). PR expression was slightly increased in females, subjects aged under 55 y, those with ulceration, non-acral subtype and diagnosis delay longer than 1 y, but the difference was not statistically significant. Selective expression of progesterone receptor in malignant melanoma might be correlated with inhibited tumor growth.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
Skin
/
Skin Neoplasms
/
Immunohistochemistry
/
Receptors, Progesterone
/
Gene Expression Regulation, Neoplastic
/
Proliferating Cell Nuclear Antigen
/
Melanoma
/
Models, Biological
Type of study:
Prognostic study
Language:
English
Journal:
Journal of Huazhong University of Science and Technology (Medical Sciences)
Year:
2008
Type:
Article
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