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IL-17 contributes to autoimmune hepatitis / 华中科技大学学报(医学)(英德文版)
Journal of Huazhong University of Science and Technology (Medical Sciences) ; (6): 443-6, 2010.
Article in English | WPRIM | ID: wpr-634840
ABSTRACT
The role of interleukin-17 (IL-17) in autoimmune hepatitis (AIH) was investigated. A mouse model of experimental autoimmune hepatitis was established, and the syngeneic S-100 antigen emulsified in complete Freud's adjuvant was injected intraperitoneally into adult male C57BL/6 mice. The IL-17 expression in serum and the livers of the mice models was detected by using ELISA and immunohistochemistry, respectively. IL-17 neutralizing antibody was used to study the biological effect of IL-17 in the experimental AIH. IL-17 neutralizing antibody in vivo administration alleviated the hepatic inflammation and ALT level in the AIH model. IL-17 in the peripheral blood mononuclear cells (PBMC) of AIH patients was measured by using real-time PCR method. The results showed that IL-17 level was significantly up-regulated in AIH patients and mice models. It was concluded that IL-17 contributed to the development of AIH and might be a potential therapeutic target of AIH.
Full text: Available Index: WPRIM (Western Pacific) Language: English Journal: Journal of Huazhong University of Science and Technology (Medical Sciences) Year: 2010 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: English Journal: Journal of Huazhong University of Science and Technology (Medical Sciences) Year: 2010 Type: Article