Association of HLA-DRB1, DQB1 alleles with chronic urticaria / 华中科技大学学报(医学)(英德文版)
Journal of Huazhong University of Science and Technology (Medical Sciences)
;
(6): 354-6, 2005.
Article
in English
| WPRIM
| ID: wpr-634862
ABSTRACT
In order to investigate the association of genotypes of HLA-DRB1 and HLA-DQB1 alleles with the genetic susceptibility of chronic urticaria (CU), genotypes of HLA-DRB1 and HLA-DQB1 genes were detected by polymerase chain reactions with sequence-specific primers (PCR-SSP) in 42 patients with CU (19 men and 23 women, mean age 30.67+/-12.45 y old as well as 193 racially matched healthy persons in ethnic Han from Hubei provinece. Gene frequencies of HLA-DRB1 * 12, * 0901 (RR=3.11, chi2=7. 579, P=0.006; RR= 2.47, chi2 =5.684, P=0.017) were significantly increased in CU patients as compared with that in healthy people. Gene frequencies of HLA-DQB1 * 05 (RR=0.26, chi2=6.683, P=0.01) were significantly decreased in CU patients. It was suggested that CU was found strongly associated with HLA-DRB1 * 12, * 0901 and HLA-DQB1 * 05, the former might be the genetic markers for susceptibility to CU, but the latter might play a resistive role.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Urticaria
/
HLA-DQ Antigens
/
HLA-DR Antigens
/
Polymerase Chain Reaction
/
Chronic Disease
/
Genetic Predisposition to Disease
/
Alleles
/
Gene Frequency
/
Genotype
Language:
English
Journal:
Journal of Huazhong University of Science and Technology (Medical Sciences)
Year:
2005
Type:
Article
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