Reconstruction of Rat Abdominal Aota with Jugular Vein Homografts Pretreated by Polyepoxy Compound / 上海第二医科大学学报

ABSTRACT

ObjectiveTo evaluate a new cross-linking reagent—polyepoxy compound(PC)in vivo. MethodsTo reconstruct abdominal aota with jugular homografts of SD rats (diameter 0.8～1.1mm) pret4reated by glycero polyglycidyl ether(a kind of PC) or glutaraldehyde(GA). Grafts were explanted at different elapsed time, and their histological changes were studied. ResultsThere was no difference between the patencies of the PC and GA prepared homografts ( P >0.05), but the inci-dence of aneurysms in GA is higher than that in PC group ( P < 0.05). The healing procedures of endothelial cells in two experimental groups were basically same at the end of second month after transplantation. The endothelial cells cover the whole inner wall of the grafts. ConclusionCompaired PC graft with GA graft, it shows that PC are more unbreakable and compliant, lower rate of aneurysms and less calcification. PC might be a potential vessel-crosslink-reagent.