IL-1βand IL-8 in the serum of patients with vernal keratoconjunctivitis / 中华实验眼科杂志

ABSTRACT

To investigate the role of interleukin-l beta(IL-1β)and interleukin-8(IL-8) in the pathogenesis of vernal keratoconjunctivitis.MethodsThe levels of two cytokines of peripheral blood serum were determined with radioimmunoassay in 13 volunteers,13 patients with quiet vernal keratoconjunctivitis and 13 patients with active vernal keratoconjunctivitis.ResultsIL-1βserum levels in active and quiet vernal keratoconjunctivitis were(0.134 6±0.022 9)ng/ml,(0.213 1±0.036 0)ng/ml,IL-8 serum levels in active and quiet vernal keratoconjunctivitis were(0.230 4±0.014 5)ng/ml,(0.323 8±0.036 9)ng/ml,which were higher than(0.075 0±0.010 8)ng/ml,(0.67 2±0.023 1)ng/ml of normal controls,and the differences among the three groups were statistically significant(P<0.001).ConclusionIL-1β and IL-8 might play a significant role in the pathogenesis of vernal keratoconjunctivitis,and their possible roles in estimating and treating the diesease are worthy of further investigation.