Current research in herpetic keratitis following excimer laser corneal refractive keratectomy / 中华实验眼科杂志

ABSTRACT

Herpes simplex virus infection after excimer laser corneal refractive surgery often leads to serious complications,and the main reasons to induce the infection of herpes simplex virus areirradiation of excimer laser and stimulation of corneal by surgery;long-term topical administration of steroids eye drops,or the interaction of all above factors.Once the herpetic keratitis appears,early and correct diagnosis and management are critical for rescuing the visual acuity.The laboratory assay methods,such as serum antibody,virus culture,corneal epithelial scraping,pathological examination,polymerase chain reaction ( PCR ),can be used for the assistance of diagnosis but each methods has their own limitation ; it is recognized that the multiplex PCR seem to become more sensitive.The primary treatment method for the infection of herpes simplex virus is to use the anti-virus drug topical or systemically after excimer laser corneal refractive keratectomy.the topical use of antivirus drugs in perioperation period for patients with history of herpetic keratitis can reduce the recurrence.This paper summarized the progress in clinical and experimental researches and review the etiology,diagnosis,treatment and prevention of herpetic keratitis following excimer laser corneal refractive surgery in recent years.