Current research on effect of integrin in diabetic retinopathy / 中华实验眼科杂志

ABSTRACT

Integrin is a kind of transmembrane protein which mediates the interaction between cells and cells,cells and extracellular matrix.When activated by the ligands,integrins modify and alter the activity and function of many cytoskeleton proteins and signal molecules.Integrins are able to cooperate with growth factor receptors in several steps at both cellular membrane and downstream signaling pathway and co-adjust the adhesion,survival,growth,differentiation,proliferation and migration of the cells,constructing a network of intracellular signaling transduction system.Diabeticretinopathy ( DR )hasacloserelationshipwithproliferation,migrationand neovascularization of vascular endothelial cells driven by growth factors.Since the interaction among growth factors,growth factor receptors,cellular migration and integrins,the treatment of DR,in the future,may be shifted from a growth factor inhibition aspect to integrin inhibition pattern.The signaling pathway,relationship of integrin and growth factor,effect of integrin in DR were reviewed.