An updated view on dopamine in ophthalmology / 中华实验眼科杂志

ABSTRACT

Dopamine is one of neurotransmitters of the central nervous system,and it can activate or inhibit cAMP by binding the corresponding membrane receptor and further regulate calcium signals.Dopamine is also primary neurotransmitter and modulator in retina,and it plays very important roles over the entire visual pathway including retina,lateral geniculate body and visual cortex.Recent study showed that dopamine participates in the pathogenesis of amblyopia and myopia.In addition,it is also involved in the regulation of intraocular pressure (IOP).These studies offered some new clues for the treatment and prevention of amblyopia and myopia as well as the regulation of IOP.Hence,this paper describes the new progress of retinal dopamine in the form deprivation myopia,myopic defocus,the regulation of IOP,the eye growth and the treatment of amblyopia.