Update on apoptosis signal pathway of retinal ganglion cell / 中华实验眼科杂志

ABSTRACT

Retinal ganglion cells (RGCs) apoptosis is the ultimate pathway of many disorders involved in the retina and optic nerve,and contributes to irreversible visual loss.RGCs are vulnerable to various stimulates including ocular trauma,intraocular hypertension,endoophthalmitis and neurotoxin,and eventually undergo apoptosis.Those external stimulates can activate multiple intracellular signal pathways,and regulate apoptosis associated genes.This paper reviewed the recent findings regarding external stimulates,intracellular signaling pathways and gene regulation involved in the pathological retinal ganglion cells death,in order to provide potential targets for the development of new specific therapies for disorders associate with RGCs degeneration.