Matrix metalloproteinases/tissue inhibitors of metalloproteinase system and diabetic ocular complications / 中华实验眼科杂志
Chinese Journal of Experimental Ophthalmology
; (12): 860-864, 2014.
Article
in Zh
| WPRIM
| ID: wpr-636932
Responsible library:
WPRO
ABSTRACT
The matrix metalloproteinases/tissue inhibitors of metalloproteinase (MMPs/TIMPs) system plays an important role in the degradation and remodel of the extracellular matrix (ECM).MMPs/TIMPs system is associated with ocular physiological process,such as ocular growth and development,etc.Also,MMPs/TIMPs system is involved in ocular pathological process including inflammation,wound healing,neoangiogenesis,tumor invasion and metastasis.MMPs/TIMPs system also participats in the formation of some ophthalmic diseases such as proliferative vitreoretinopathy (PVR),proliferative diabetic retinopathy (PDR),diabetic cataract,rhegmatogenous retinal detachment (RRD),retinoblastoma (RB),age-related macular degeneration (AMD),ocular trauma,and glaucoma.This review attempts to elaborate the biological characteristics of MMPs/TIMPs,and the current researches of MMPs/ TIMPs system in the diabetic ocular complications,focusing on diabetic retinopathy,cataract and keratopathy.
Full text:
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Index:
WPRIM
Language:
Zh
Journal:
Chinese Journal of Experimental Ophthalmology
Year:
2014
Type:
Article