The role of peroxisome proliferator-activated receptors and its agonist in the ophthalmology / 中华实验眼科杂志

ABSTRACT

Peroxisome proliferator-activated receptors (PPARs) belong to the nuclear hormone receptor superfamily of ligand-dependent transcription factors.To date,three isotypes of PPARs called PPARα,PPARγ and PPARβ/δ have been identified.The relationship between PPARγ and fibrosis disease has increasingly drawn people's attention.PPARγ is activated by its ligands or agonists plays an important role in the control of fibrosis through their effects on various cellular processes,including anti-inflammatory,inducing cellular apoptosis and differentiation,anti angiogenesis,antioxidative and anti-proliferative effects,which is expected to be a new way to treat ocular diseases.The role of PPAR-γ and its agonist in ocular diseases,including PPARs and its distribution,the structure and function of PPAR-γ,PPAR-γ ligands and agonist,activation of PPAR-γ,PPAR-γ in the expression of eye tissues,and the role of PPAR-γ and its agonist in ocular diseases were reviewed.