Research progress of IGF-1R in ophthalmology / 中华实验眼科杂志

ABSTRACT

Insulin-like growth factor 1 receptor (IGF-1 R),a member of the family of tyrosine protein kinase,mediates the activity of the IGF-1.IGF-1R can promote the proliferation and migration of cells and inhibit the apoptosis of cells.IGF-1R shows a high level expression and presents a close relationship with a variety of biological characteristics such as invasion and metastasis of choroid melanoma,and it influences the pathogenesis and progress of thyroid related ophthalmopathy,working together with thyroid stimulating hormone receptor (TSHR) through different signaling pathways.Also IGF-1 R,targeting vascular endothelial growth factor (VEGF),may promote the pathogenesis and development of new retinal vascular diseases through the insulin receptor substrate 1 (IRS-1).Other IGF-1R related biological effects were found in eye diseases,such as refractive error and cataract,ect.,hinting us that as a molecular targete,IGF-1R will become a new topic of gene therapy for eye diseases.