Advances in molecular genetics of exfoliation syndrome / 中华实验眼科杂志
Chinese Journal of Experimental Ophthalmology
;
(12): 760-763, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-637573
ABSTRACT
Exfoliation syndrome (XFS),one of the most common causes of glaucoma,represents an age related,complex,multifactorial and late-onset disease worldwide.The etiopathogenesis involves both genetic and environmental factor.However,the exact etiopathogenesis of XFS is still unclear.The purpose of this review was to discuss the recent research progress of the molecular genetics of XFS.Some candidate genes linked to XFS include lysyl oxidase-like 1 (LOXL1) gene,clusterin (CLU) gene,contactin associated protein-like 2 (CNTNAP2) gene,apolipoprotein E (ApoE) gene,matrix metallo proteinases (MMPs) gene,glutathione S-transferase (GST) gene,transforming growth factor-β1 (TGF-β1) gene,tumor necrosis factor-α (TNF-a) gene and so on.These genes may be modifying genes for the development of XFS.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Experimental Ophthalmology
Year:
2015
Type:
Article
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