Interferon-gamma (IFN-gamma) increases CD1 expression through inhibition of IL-10 secretion from M.leprae-infected macrophages of lepromatous leprosy / 나학회지
Korean Leprosy Bulletin
;
: 47-54, 2000.
Article
in Korean
| WPRIM
| ID: wpr-63796
ABSTRACT
The CD1 system is a novel antigen-presenting system for T cell recognition of lipid and glycolipids in antimicrobial immunity. Lepromatous leprosy is characterized by lack of cell-mediated immunity against M.leprae. The lack of cell-mediated immunity in lepromatous leprosy has been suggested to be correlated with weak CD1 expression on antigen presenting cells. In order to define how CD1 is down-regulated on M. leprae-infected antigen-presenting cells, we examined effects of interferon-gamma(IFN-gamma) on interleukin-10 (IL-10) secretion and CD1 expression of M.leprae-infected macrophages from granuloma of lepromatous leprosy. Our results showed that a significant trend of increased CD1 expression in response to decresed IL-10 secretion from M.leprae-infected macrophages by IFN-gamma. These results suggest that the local cytokine milieu, especially the balance between IFN-gamma and IL-10, is an important determinant in the regulation of CD1 in lepromatous lesions.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Glycolipids
/
Leprosy, Lepromatous
/
Interferon-gamma
/
Interleukin-10
/
Granuloma
/
Immunity, Cellular
/
Leprosy
/
Macrophages
/
Antigen-Presenting Cells
Language:
Korean
Journal:
Korean Leprosy Bulletin
Year:
2000
Type:
Article
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