The pathological mechanism and clinical research of dendritic cells in the uveitis / 中华实验眼科杂志

ABSTRACT

Uveitis is mainly T helper cells (Th)-mediated autoimmune disease.It is one of the common eye diseases causing blindness.Dendritic cells (DCs),which are now known as the most potential professional antigen presenting cells (APCs),and can stimulate naive T-cell activation effectively.DCs are believed to be the initial factor of the immune response,which play an important role in autoimmune disease,transplantation rejection and regulation of immune homeostasis.DCs are considered to be the initial cells to cause uveitis,and may be a key factor in pathogenesis and development of uveitis.In recent years,studies have shown that DCs can interact with a variety of immune cells,regulate the balance of Th1,Th2 and Th17,induce immune tolerance and adjust the process of uveitis.The role of DCs in uveitis is attached great importance.In this paper,the basic biological characteristics of DCs or in uveal tissue,the current knowledge on the regulation mechanism of DCs in uveitis and its clinical application prospects were reviewed.