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Nationwide Population-Based Incidence and Survival Rates of Malignant Central Nervous System Germ Cell Tumors in Korea, 2005-2012 / Journal of the Korean Cancer Association, 대한암학회지
Cancer Research and Treatment ; : 494-501, 2017.
Article in English | WPRIM | ID: wpr-63854
ABSTRACT

PURPOSE:

Malignant central nervous system (CNS) germ cell tumors (GCTs), although rare, are thought to occur more frequently among Asians. However, a recent population-based study revealed no differences in GCT incidence between Asians and Caucasians. Therefore, this study was conducted to determine the incidence and survival rates of CNS GCTs using the national cancer incidence database, and to compare these rates to those in the United States and Japan. MATERIALS AND

METHODS:

We extracted CNS GCT patients diagnosed between 2005 and 2012 from the Korea Central Cancer Registry database. Age-standardized rates (ASRs), annual percentage change, and the male-female incidence rate ratios (IRRs) were calculated. To estimate the survival rate, we used data for patients diagnosed between 2005 and 2010 and followed their cases until December 31, 2013.

RESULTS:

The ASR for CNS GCT between 2005 and 2012 was 0.179 per 100,000 (95% confidence interval, 0.166 to 0.193), with an overall male-to-female (MF) IRR of 2.951. However, when stratified by site, the MF IRR was 13.621 for tumors of the pineal region and 1.871 for those located in nonpineal regions. The most frequent histologic type was germinoma (76.0%), and the most frequent location was the suprasellar region (48.5%). The 5-year survival rate of germinoma patients was 95.3%.

CONCLUSION:

The incidence rate of CNS GCTs in Korea during 2005-2012 was 0.179 per 100,000, which was similar to that of the Asian/Pacific Islander subpopulation in the United States. Moreover, the CNS GCT survival rate in Korea was similar to rates in Japan and the United States.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: United States / Central Nervous System / Incidence / Survival Rate / Germinoma / Neoplasms, Germ Cell and Embryonal / Asian People / Germ Cells / Japan / Korea Type of study: Incidence study / Prognostic study Limits: Humans Country/Region as subject: North America / Asia Language: English Journal: Cancer Research and Treatment Year: 2017 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: United States / Central Nervous System / Incidence / Survival Rate / Germinoma / Neoplasms, Germ Cell and Embryonal / Asian People / Germ Cells / Japan / Korea Type of study: Incidence study / Prognostic study Limits: Humans Country/Region as subject: North America / Asia Language: English Journal: Cancer Research and Treatment Year: 2017 Type: Article