Effect of Low-Dose Hydrocortisone on Expression of Hippocampus Nuclear Factor-Kappa B,Inhibitory Kappa Bin Lipopolysaccharide-Induced Septic Rats / 实用儿科临床杂志
Journal of Applied Clinical Pediatrics
;
(24)1992.
Article
in Chinese
| WPRIM
| ID: wpr-638723
ABSTRACT
Objective To investigate the effect of low-dose hydrocortisone(HC)on hippocampus nuclear factor kappa B((NF-?B)),I?B expression in lipopolysaccharide(LPS)induced septic rats and the role of NF-?B signal transcription pathway in pathogenesis.Methods Fifty-four rats were randomly divided into 3 groups control group(A group,n=6),model group(B group,n=24),low-dose HC treatment group(C group,n=24).The septic rat model was established by intraperitoneal injection LPS(1 mg/kg),as the intervention by caudal vein injection low-dose HC(6 mg/kg),each of B and C group was subdivied into 2,8,16,24 hours respectively after LPS injection(n=6).At serial time points,the animals in each group were sacrificed,brain tissue samples were harvested to determine NF-?B,I?B expression by immunhistochemistry in hippocampus.Results In B group NF-?B expression was up regulated compared with A group(P
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Prognostic study
Language:
Chinese
Journal:
Journal of Applied Clinical Pediatrics
Year:
1992
Type:
Article
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