The Effect of NK-1 Receptor Antagonist on the Enhanced Response to Bradykinin by Mustard Oil Treatment of the Rat Uterus / 대한산부인과학회잡지
Korean Journal of Obstetrics and Gynecology
;
: 1325-1331, 2003.
Article
in Korean
| WPRIM
| ID: wpr-63891
ABSTRACT
OBJECTIVE:
To find out wheather the substance P takes part in the pain mediating system of uterus, and to ascertain the role of substance P in the hypersensitivity of hypogastric nerve to bradykinin during the uterine inflammation.METHODS:
The uterus has two sensory innervations, which are the hypogastric nerve and the pelvic nerve. Since the hypogastric nerve is known to show increased sensitivity to bradykinin, a pain mediator, when the uterus is in inflammatory state, the hypogastric nerve recording was done for electrophysiological study of uterine pain-mediating mechanism in female SD rats (200-250 g). NK1 receptor antagonist (L-703,606) was injected through uterine artery before injecting bradykinin while uterus was under inflammation.RESULTS:
The NK-1 receptor antagonist (L-703,606) decreased the spontaneous nerve impulse during inflammation, and it also decreased the hypersensitivity of the hypogastric nerve to bradykinin during the uterine inflammation.CONCLUSION:
Substance P mediates the pain sense of hypogastric nerve, and it also plays a role in increased sensitivity of hypogastric nerve to bradykinin while uterus is in inflammatory state.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Uterus
/
Action Potentials
/
Bradykinin
/
Substance P
/
Negotiating
/
Receptors, Neurokinin-1
/
Uterine Artery
/
Hypersensitivity
/
Inflammation
/
Mustard Plant
Limits:
Animals
/
Female
/
Humans
Language:
Korean
Journal:
Korean Journal of Obstetrics and Gynecology
Year:
2003
Type:
Article
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