Expression of Cyclooxygenase-2 and Survivin in Children with Acute Leukemia and Its Significance / 实用儿科临床杂志
Journal of Applied Clinical Pediatrics
; (24)2006.
Article
in Zh
| WPRIM
| ID: wpr-639306
Responsible library:
WPRO
ABSTRACT
Objective To study the expression of cyclooxygenase-2(COX-2) and survivin in children with acute leukemia(AL) and its significance.Method The expression of COX-2 and survivin were determined by immunohistochemical SABC assay.Results The expression rate of COX-2 and survivin were 52.4%(22/42 cases)and 45.2%(19/42 cases)in AL,and the expression rate of COX-2 and survivin were 46.9%(15/32 cases)and 40.6%(13/32 cases)and in acute lymphonate leukemia(ALL),both of them were higher than those in control group(Pa0.05).The positive rate of COX-2 was 84%(16/19 cases)in 19 cases with survivin positive expression,and the negative rate of COX-2 was 85%(17/20 cases)in 20 cases with survivin negative expression,and there was positive correlation between COX-2 expression and survivin expression(r=0.579 P
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Index:
WPRIM
Language:
Zh
Journal:
Journal of Applied Clinical Pediatrics
Year:
2006
Type:
Article