Clinical Characteristics and Immune Function Change of Cytomegalovirus Infection in Newborn Infants and Little Infants / 实用儿科临床杂志

ABSTRACT

Objective To explore the clinical manifestations,diagnosis and treatment,restoration of disease and immune function change of pediatric patients infected by cytomegalovirus (CMV). Methods The clinical manifestations of 52 CMV patients15 cases (29%) of common infections,12 cases (23%) of hepatitis,11cases (21%) of inflammatory reactions,6 cases (12%) of pneumonia,4 cases (7%) of rash,2 cases (4%) of CMV encephalitis and 2 cases of (4%) intrauterine growth restriction. The examination of peripheral blood,including leucocyte counts and classification and platelet counts,were performed twice,6 ?L/time. C-reaction protein (CRP) using femoral vein were tested right after admission and during treatment period. The molecular biology technique was used to detect pathogens. Liver function examination was also performed. Moreover,the examination of cell immune function was done using the flow cytometer to test lymphocyte counts.Results 1.Blood testwhite blood counts of 2 cases (4%) exceeded 20?109 L-1,and 18 cases (35%) in the area of (10-20)?109 L-1,the other patients were all normal.The lymphocyte counts in 46 cases (88%) increased and the thrombocyte counts in 12 cases (23%) were less than 100?109 L-1,the lymphocyte and thrombocyte counts of other patients were all normal.2.CRP11 cases (21%) exceeded 20 mg/L,others were