Serum Concentration Monitoring and High-Dose Methotrexate Chemotherapy for Osteosarcoma in Children / 实用儿科临床杂志

ABSTRACT

1.0 ?mol/L),the toxicity and side effects of MTX increased significantly.The most common drug side effects were gastrointestinal symptoms and leucopenia.The oral mucosal lesions became worse in 12 g/m2 group.Conclusion The monitoring of HD-MTX plasma concentration provides an objective clinical basis for the individualized chemotherapy.