Influence of Dexamethasone and Fructose-1,6-Diphosphate on Myocardial Enzymes and Ultrastructure of Myocardial Cells in Rats with Endotoxemia / 实用儿科临床杂志
Journal of Applied Clinical Pediatrics
;
(24)1992.
Article
in Chinese
| WPRIM
| ID: wpr-640238
ABSTRACT
Objective To investigate the effect of dexamethasone(DXM)and fructose-1,6-diphosphate(FDP)on cardial troponin I(cTnI)and MB isoenzyme of creatine kinase(CK-MB),and ultrastructure of myocardial cells in rats with endotoxemia.Methods Eighty SD rats were randomly divided into 4 groupssodium chloride group(NS group,n=8),9 g?L-1 NS 1 mL,ip;lipopolysaccharide group(LPS group,n=24),administered with endotoxin(5 mg?kg-1,ip);DXM group(n=24)received DXM(5 mg?kg-1,ip)after injection of LPS 1 h;FDP(n=24)group,received FDP(1 g?kg-1,ip)after injection LPS 1 h.Then,they were sacrificed at 6 h,12 h,24 h and 72 h after injection.CK-MB and cTnI in blood were detected with chemiluminescent techniques,and myocardial pathological damage was observed under the light and transmission electron microscope.Results Compared with control group,in LPS group,the serum cTnI and CK-MB were increased significantly from 6 h to 24 h with time going by(P
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Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of Applied Clinical Pediatrics
Year:
1992
Type:
Article
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