Correlation between Pulmonary Hypertension Induced by High Blood Flow and Nuclear Factor-?B / 实用儿科临床杂志

ABSTRACT

Congenital heart disease with left-to-right shunt easily lead to pulmonary hypertension.Currently agreed about its mechanismshear stress induced by high pulmonary blood flow stimulus pulmonary endothelium,to start regulation of genetic transcription,to initiate a series of molecular biology and pathophysiology changes,and finally to lead to pulmonary vascular pathologic remolding.Nuclear factor(NF)-?B is a kind of nuclear factor with multiple biological effect and play an important role in pulmonary vascular remolding.NF-?B signal can be actiacted by high blood flow.Its target gene products,for example,vasoactive mediators,cytokines,make pulmonary vessels difficulty to maintain the normal structure and cause pulmonary vascular contraction and remolding,thus,pulmonary arterial pressure increases.