The effect of nitric oxide/endothelins system on the hepatic ischemia/reperfusion injury / 华中科技大学学报(医学)(英德文版)
Journal of Huazhong University of Science and Technology (Medical Sciences)
; (6): 216-7, 227, 2002.
Article
in En
| WPRIM
| ID: wpr-640946
Responsible library:
WPRO
ABSTRACT
The relationship between the hepatic ischemia/reperfusion (I/R) injury and the balance of nitric oxide/endothelins (NO/ET) was studied. The changes of the ratio of NO/ET and the hepatic injury were observed in a rat hepatic I/R model pretreated with several tool drugs. In the acute phase of hepatic I/R injury, the ratio of plasma NO/ET was reduced from 1.58 +/- 0.20 to 0.29 +/- 0.05 (P < 0.01) and the hepatic damage deteriorated. NO donor L-Arg and ET receptor antagonist TAK-044 could alleviate the hepatic I/R injury to some degree, whereas NO synthase inhibitor L-NAME aggravated the damage. It was concluded that the hepatic I/R injury might be related with the disturbance of the NO/ET balance. Regulation of this balance might have an effect on the I/R injury.
Full text:
1
Index:
WPRIM
Main subject:
Arginine
/
Reperfusion Injury
/
Endothelins
/
Receptors, Endothelin
/
NG-Nitroarginine Methyl Ester
/
Liver
/
Nitric Oxide
Type of study:
Prognostic_studies
Language:
En
Journal:
Journal of Huazhong University of Science and Technology (Medical Sciences)
Year:
2002
Type:
Article