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Transcription and translation of Dickkopf-1 in endometrium of pregnant mice during the peri-implantation period / 华中科技大学学报(医学)(英德文版)
Journal of Huazhong University of Science and Technology (Medical Sciences) ; (6): 625-7, 638, 2004.
Article in English | WPRIM | ID: wpr-640985
ABSTRACT
To study the expression of Dickkopf-1 (DKK-1) in endometrium of pregnant mice during the peri-implantation period and the role of DKK-1 during the embryo implantation in mice. Immunohistochemical technique was employed to determine the location of DKK-1 protein in endometrium, and semiquantitative reverse transcriptase polymerase chain reaction (RT-PCR) was utilized to determine the levels of DKK-1 mRNA. Our results showed that the expressions of DKK1 mRNA and protein were higher in experimental groups than in control group (P<0.01) and it increased significantly on day 3 and reached its peak on day 4, and then decreased gradually on day 5-7. The levels of DKK-1 mRNA and protein on day 4 was significantly higher than those of other groups (P<0.01). It is concluded that DKK-1 probably plays an important role in signal transudation of embryo implantation and its high expression indicates the opening of implantation window.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Embryo Implantation / Transcription, Genetic / Protein Biosynthesis / RNA, Messenger / Intercellular Signaling Peptides and Proteins / Endometrium Language: English Journal: Journal of Huazhong University of Science and Technology (Medical Sciences) Year: 2004 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Embryo Implantation / Transcription, Genetic / Protein Biosynthesis / RNA, Messenger / Intercellular Signaling Peptides and Proteins / Endometrium Language: English Journal: Journal of Huazhong University of Science and Technology (Medical Sciences) Year: 2004 Type: Article