Preparation of arsenic trioxide albumin microspheres and its release characteristics in vitro / 华中科技大学学报(医学)(英德文版)
Journal of Huazhong University of Science and Technology (Medical Sciences)
;
(6): 310-2, 319, 2005.
Article
in English
| WPRIM
| ID: wpr-641010
ABSTRACT
Arsenic trioxide albumin microspheres (As2O3-BSA-NS) were prepared by using methods of chemical cross-linking. The desirability function (DF), calculated according to the size (0.05). The release experiment in vitro showed that As2O3 in As2O3-BSA-NS was released more slower than pure As2O3. It was concluded that regular As2O3-BSA-NS may be prepared by the methods of chemical cross-linking, which was optimized by orthogonal experimental analysis of different factors, and the microspheres can release As2O3 slowly.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Oxides
/
Arsenicals
/
Serum Albumin, Bovine
/
Drug Carriers
/
Technology, Pharmaceutical
/
Drug Delivery Systems
/
Cross-Linking Reagents
/
Delayed-Action Preparations
/
Microspheres
Language:
English
Journal:
Journal of Huazhong University of Science and Technology (Medical Sciences)
Year:
2005
Type:
Article
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