Current researches of function and mechanism of peroxisome proliferator-activated receptor-γ in diabetic retinopathy / 中华实验眼科杂志

ABSTRACT

Peroxisome proliferator-activated receptor gamma (PPAR-γ),a member of the nuclear receptor superfamily,plays a great role in delaying or even preventing the occurrence and/or development of diabetic retinopathy (DR),a complicated out-of-control waterfall-like pathophysiological processes.DR is characterized by pathways,such as inflammatory reactions,the generation of advanced glycation end products,oxidative stress,protein kinase C and so on.As one of the most important metabolic homeostasis and adipocyte differentiation regulator,the single nucleotide polymorphism and molecular structure of PPAR-γ have been proven to impact on anti-inflammation,anti-neovascularization and fibration,antioxidation,insulin sensitizer and anti-apoptosis in DR.This review provided a summary of the function and mechanism researches on PPAR-γand offered new ideas of prevention and therapy in DR.