Clinical observation of cutting fluctuations on central corneal thickness after laser subepithelial keratomileusis / 国际眼科杂志(Guoji Yanke Zazhi)

ABSTRACT

AIM:To evaluate the percentage of cutting fluctuations of central corneal thickness (CCT) intraoperative used low concentration (0.02%) mitomycin C (MMC) after laser-assisted subepithelial keratomileusis (LASEK).METHODS:In this prospective study, low and medium myopia group(spherical equivalent≤6.0DS) has 138 patients (276 eyes).Low concentration MMC used topically in 69 patients(138 eyes)randomized after excimer laser ablation;the another traditional LASEK as control.High myopia group(6.0DSpatients (164 eyes).Low concentration MMC used topically in 41 patients (82 eyes), the another traditional LASEK as control.The different measured value and percent of change between actual CCT and predicted CCT were recorded at l, 2, 3, 6, 9 and 12mo after LASEK.Corneal parameters were compared using paired t test and their repeatability was assessed using the coefficient of variation (CV).

RESULTS:

At 3mo after operation, the difference of central corneal thickness and cutting value between different treatment groups was statistically significant(P<0.05).The percentage of cutting fluctuations, which used to avoid the interference of the individual central corneal thickness between the applying low concentration MMC group and control groupthe minimum value achieved at 1mo after LASEK, the maximum value achieved at 3mo after LASEK, the difference was statistically significant compared with the other 5 periods after LASEK within group(P<0.05);the difference in each period after LASEK was statistically significant(P<0.05) between groups with different treatmemt(P<0.05).

CONCLUSION:

The study on percentage of cutting fluctuations of central corneal thickness, further confirmed low concentrations MMC in reducing postoperative corneal stromal proliferation reaction, inhibition of haze production.