Effect of ginsenoside-Rg3 on the expression of VEGF and TNF-α in retina with diabetic rats / 国际眼科杂志(Guoji Yanke Zazhi)
International Eye Science
;
(12): 1855-1857, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-641416
ABSTRACT
AIM:
To investigate the effect of ginsenoside-Rg3 on the expression of vascular endothelial growth factor (VEGF) and tumor necrosis factor-α (TNF-α) in retina with diabetic rats and its roles in preventing neovascularization in diabetes.METHODS:
Sixty male Wistar rats were divided into 3 groups randomly negative control group, diabetic control group and ginsenoside-Rg3 treatment group (5mg/kg, 0.2mg/mL) followed by establishing diabetic model. The expression of VEGF and TNF-α were measured after 8 weeks.RESULTS:
There were significant differences among negative control group, diabetic control group and ginsenoside-Rg3 treatment group in the expression of VEGF and TNF-α (F=129.363, 211.992; all the P<0.01). VEGF and TNF-α expression were significantly higher in diabetic control group and ginsenoside-Rg3 treatment group than that in negative control group (P<0.01), with a significant reduction in ginsenoside-Rg3 treatment group than that in diabetic control group (P<0.01).CONCLUSION:
Ginsenoside-Rg3 can down-regulate the expression of VEGF and TNF-α in retina, which may interfere in the development of diabetic retinopathy.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Prognostic study
Language:
Chinese
Journal:
International Eye Science
Year:
2010
Type:
Article
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