Acute reversible lens opacity affects retinal HRA+OCT imaging in mice / 国际眼科杂志(Guoji Yanke Zazhi)
International Eye Science
;
(12): 21-22, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-641465
ABSTRACT
AIM:
To assess the affect of ketamine and xylazine (ketamine/xylazine) to the transient lens opacity in mice.METHODS:
Kimba mice (n=10) and wild-type mice (wt, n=8) were sedated with intraperitoneal injection of ketamine (60mg/kg for mice) and xylazine (10mg/kg) at 4, 8, 12 and 16 weeks old respectively. Pupils were dilated with tropicamide 25g/L alone to allow imaging lens status and retina using Spectralis HRA+OCT.RESULTS:
All Kimba mice and wt presented extreme proptosis, suppression of the eye-blink reflex, corneal surface drying and lens opacities which occurred as early as 21±6 minutes after giving anesthesia and the lens opacities lasted up to 150±24 minutes.CONCLUSION:
Ketamine/xylazine can cause transient lens opacity that may be related with the drugs side-effect.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
International Eye Science
Year:
2010
Type:
Article
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