Increased expression of Ets-1 in the diabetic retina of streptozotocin-induced rat model / 国际眼科杂志(Guoji Yanke Zazhi)
International Eye Science
;
(12): 19-22, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-641705
ABSTRACT
AIM:
To determine the involvement of Ets-1 in the pathological progress of the experimental diabetic retina.METHODS:
Diabetes was induced by intraperitoneal injection of STZ. Total RNA and Total proteins were isolated from retinas of experimental and control eyes at 4 weeks after STZ-injection and were assessed by Northern blot analysis and Western blot analysis, respectively.RESULTS:
Expression of both Ets-1 mRNA and Ets-1 protein was significantly increased in the experimental diabetic rat's retina after STZ-injection compared with the control group (P<0.001).CONCLUSION:
Our results indicated that Ets-1 was involved in the pathological progress of experimental diabetic retina.Further studies should be conducted to focus on the relationship between Ets-1 and VEGF in the diabetic retina.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
International Eye Science
Year:
2007
Type:
Article
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