The significance and expression of HIF-1α and COX-2 in the retinal neovascularization / 国际眼科杂志(Guoji Yanke Zazhi)
International Eye Science
;
(12): 748-750, 2006.
Article
in Chinese
| WPRIM
| ID: wpr-641735
ABSTRACT
AIM:
To investigate the expression and significance of hypoxia-inducible factor -1α (HIF-1α)and Cyclooxygenase-2(COX-2) in the retinal neovascularization.METHODS:
Mouse model of hyperoxia-induced ischemic retinopathy were established. A novel flucorescein-dextran perfusion method has been developed to assess the vascular pattern. histological methods were used to count blood vessel profiles in the inner retina with HE staining.HIF-1α and COX-2 expression in the retina was determined by immunohistochemical method.RESULTS:
Lots of neovascularization were seen in hyperoxia group. The number of nuclei of proliferative retinal vessels increased significantly as compared with normal control group (P<0.001). The expression of HIF -1α was noted in the ganglion cells and retinal blood vessels. The expression of COX-2 was noted in the inner nuclear layer and ganglion cells and retinal blood vessels.CONCLUSION:
There are the expression of HIF-1α and COX-2 in the retinal neovascularization and they have correlation.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Prognostic study
Language:
Chinese
Journal:
International Eye Science
Year:
2006
Type:
Article
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