COX-2 and its inhibitor Celecoxib in corneal neovascularization / 国际眼科杂志(Guoji Yanke Zazhi)
International Eye Science
;
(12): 523-526, 2006.
Article
in Chinese
| WPRIM
| ID: wpr-641749
ABSTRACT
AIM:
To observe the expression of COX-2 in rat corneal neovascularization (CNV) and its relationship to CNV, and to explore the inhibition of Celecoxib, a COX-2 inhibitor, to CNV.METHODS:
The distribution and quantification of COX-2and VEGF was detected by immunohistochemistry. Expression of COX-2 and VEGF mRNA was quantified by RT-PCR.The difference in protein and mRNA expressions of COX-2and VEGF was analyzed to find the correlation between them.RESULTS:
Expression of activated COX-2 and VEGF protein and mRNA in CNV had a dynamic change. VEGF and COX-2co-localized. Compared with the control group, expression of both protein, mRNA of COX-2 and VEGF in experimental group Ⅱ and Ⅲ had significant difference (P<0.05), indicating the correlation between COX-2 and VEGF, while that in experimental group I had no statistical difference (P>0.05).CONCLUSION:
COX-2 expression was up-regulated in inflammatory CNV. COX-2 modulates the expression of VEGF,playing a very important role in CNV. Celecoxib inhibit COX-2expression so as to hold back the CNV.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
International Eye Science
Year:
2006
Type:
Article
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