A new method of duplication of the chronic intraocular hypertension model: underwater electrocoagulation / 国际眼科杂志(Guoji Yanke Zazhi)
International Eye Science
;
(12): 1090-1092, 2005.
Article
in Chinese
| WPRIM
| ID: wpr-641785
ABSTRACT
AIM:
To study the experimental method of inducing the chronic intraocular hypertension in rat eyes.METHODS:
Twenty Wistar rats were randomly divided into ocular hypertension and Sham control groups. Intraocular pressure (IOP) was raised by electrocoagulating at least 3 episcleral and limbal veins on the right eye of each rat in ocular hypertension group and its contralateral eye was used as control. At 1, 2, 3, 4 and 8wk after the electrocoagulation of the veins, IOP were measured.RESULTS:
The treatment of electrocoagulation caused a significant IOP increase of the right eyes over the baseline, over the contralateral eyes, and over the sham control eyes (repeated measures ANOVA, P<0.001). At 1wk,IOP was (30.12± 5.L8 ) mmHg (1kPa=7.5mmHg), and maintained the high IOP up to 8wk.CONCLUSION:
The chronic intraocular hypertension model could be successfully created by electrocoagulating three or more episcleral and limbal veins.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
International Eye Science
Year:
2005
Type:
Article
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