Preliminary Suggestion about Staging of Anorectal Malignant Melanoma May Be Used to Predict Prognosis / Journal of the Korean Cancer Association, 대한암학회지
Cancer Research and Treatment
;
: 240-249, 2016.
Article
in English
| WPRIM
| ID: wpr-64183
ABSTRACT
PURPOSE:
Anorectal malignant melanomas (AMM) are rare and have poor survival. The study aims to evaluate the clinicopathologic characteristics and outcomes of patients with AMM, and to devise a staging system predictive of survival outcome. MATERIALS ANDMETHODS:
This was a retrospective study of 28 patients diagnosed with, and treated for AMM. Patients classified by clinical staging of mucosal melanoma (MM) were reclassified via rectal and anal TNM staging. Survival outcomes were compared among patients grouped by the three different staging systems.RESULTS:
The three staging systems were equated with similar figures for 5-year overall survival (OS) and 5-year disease-free survival (DFS) of patients diagnosed with stage I disease. Patients (n=19) diagnosed with MM stage II disease were reclassified by rectal TNM staging into three subgroups IIIA, IIIB, and IIIC. For these patients, both 5-year OS and 5-year DFS differed significantly between the subgroups IIIA and IIIC (OS IIIA vs. IIIC, 66.7% vs. 0%, p=0.002; DFS IIIA vs. IIIC, 51.4% vs. 0%, p < 0.001).CONCLUSION:
The accuracy of prognosis in patients diagnosed with AMM and lymph node metastasis has improved by using rectal TNM staging, which includes information regarding the number of lymph node metastases.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
Rectum
/
Retrospective Studies
/
Disease-Free Survival
/
Lymph Nodes
/
Melanoma
/
Neoplasm Metastasis
/
Neoplasm Staging
Type of study:
Observational study
/
Prognostic study
/
Risk factors
Limits:
Humans
Language:
English
Journal:
Cancer Research and Treatment
Year:
2016
Type:
Article
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