Clinical study on intravitreal injection of cannabinoid HU - 211 for optic nerve damage in glaucoma rats / 国际眼科杂志(Guoji Yanke Zazhi)
International Eye Science
;
(12): 1584-1586, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-642106
ABSTRACT
To evaluate the protective effects of intravitreal injection of cannabinoid HU - 211 for optic nerve in glaucoma rats, providing the experimental evidence in the treatment of glaucoma optic nerve injury. ●METHODS:
Glaucoma rats (18 eyes) were modeled by electric coagulation sclera surface vein and randomized into 3 groups, group A received intravitreal injection of 1mg/ 0. 1mL cannabinoid HU - 211 every other day respectively; group B was given intravitreal injection of 0. 1mL water every other day, group C was high intraocular pressure (lOP) group, 6 eyes were randomly selected for blank control group ( group D). lOP was observed every day. The rats were sacrificed after treatment 4wk, froze retina section, HE stain. The density fluctuation of retinal ganglion cell ( RGC ) neurons assessment the optic nerve of rat model with chronic high lOP glaucoma were measured. ●RESULTS:
The apoptosis and damage degree of RGC in group B was obviously higher than that in group A, with statistically significant difference (P0. 05). ●CONCLUSlON lntravitreal injection of cannabinoid HU-211 shows obvious protective effect on optic nerve in glaucom rat models.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Controlled clinical trial
Language:
Chinese
Journal:
International Eye Science
Year:
2014
Type:
Article
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