Antimicrobial Susceptibility Patterns and Macrolide Resistance Genes of beta-Hemolytic Viridans Group Streptococci in a Tertiary Korean Hospital
Journal of Korean Medical Science
;
: 791-794, 2007.
Article
in English
| WPRIM
| ID: wpr-64223
ABSTRACT
The aim of this study was to investigate antimicrobial susceptibilities and macrolide resistance mechanisms of beta-hemolytic viridans group streptococci (VGS) in a tertiary Korean hospital. Minimum inhibitory concentrations (MICs) of seven antimicrobials were determined for 103 beta-hemolytic VGS isolated from various specimens. The macrolide resistance mechanisms of erythromycin-resistant isolates were studied by the double disk test and polymerase chain reaction (PCR). The overall resistance rates of beta-hemolytic VGS were found to be 47.5% to tetracycline, 3.9% to chloramphenicol, 9.7% to erythromycin, and 6.8% to clindamycin, whereas all isolates were susceptible to penicillin G, ceftriaxone, and vancomycin. Among ten erythromycin-resistant isolates, six isolates expressed a constitutive MLSB (cMLSB) phenotype, and each of the two isolates expressed the M phenotype, and the inducible MLSB (iMLSB) phenotype. The resistance rates to erythromycin and clindamycin of beta-hemolytic VGS seemed to be lower than those of non-beta-hemolytic VGS in our hospital, although cMLSB phenotype carrying erm(B) was dominant in beta-hemolytic VGS.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Penicillin G
/
Phenotype
/
Tetracycline
/
Ceftriaxone
/
Clindamycin
/
Vancomycin
/
Chloramphenicol
/
Erythromycin
/
Polymerase Chain Reaction
/
Cross Infection
Limits:
Humans
Country/Region as subject:
Asia
Language:
English
Journal:
Journal of Korean Medical Science
Year:
2007
Type:
Article
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