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Effects of smoking and alcohol drinking on arsenic metabolism of people exposed to different concentrations of arsenic in drinking water / 中国地方病学杂志
Chinese Journal of Endemiology ; (6): 28-31, 2012.
Article in Chinese | WPRIM | ID: wpr-642492
ABSTRACT
Objective To explore the effects of smoking and alcohol drinking on arsenic metabolism of people exposed to different concentrations of arsenic in drinking water.Methods Residents in Shanxi exposed to different concentrations of arsenic in drinking water and age ≥ 18 years old adults were chosen as the subjects for this study in 2008,the subjects were divided into three groups according to the concentrations of arsenic in drinking water high-arsenic exposure group (more than 0.05 mg/L),low-arsenic exposure group (between 0.01 and 0.05 mg/L) and control group(less than 0.01 mg/L),excluded recently had eaten seafood and had poisoning symptoms of chronic arsenic in drinking water in the crowd.Smoking and alcohol drinking habits were investigated by questionnaire.Arsenic species in the urine samples were detected with hydride generation atomic absorption spectroscopy.Total arsenic(tAs) was the sum of iAs%,MMA% and DMA%.iAs%,MMA% and DMA% were calculated as iAs/tAs,MMA/tAs and DMA/tAs,respectively.The first methylation ratio(FMR) and the secondary methylation ratio(SMR) were calculated as (MMA + DMA)/tAs and DMA/(MMA + DMA),respectively.Results Three hundred and ninety-five adults were chosen in this study.In the high exposure group the alcohol drinking and smoking subjects had higher MMA%(16.24%) but lower SMR(82.19% ) than the non-drinking and non-smoking subjects (12.16% and 86.13%,respectively).The differences of both MMA% and SMR were significant(P < 0.05 ).No significant difference was observed between the non-smoking/non-drinking subjects and the smoking or the drinking subjects(all P > 0.05 ).In the low exposure group there were higher MMA%( 13.86%,13.99%) lower DMA%(72.87%,77.76%)and lower SMR (83.48%,83.90% ) in those with smoking or drinking/smoking compared with the non-drinking and non-smoking subjects (11.83%,80.35% and 86.54%,respectively,all P <0.05 ).No significant difference was observed between drinkers and non-drinking/non-smoking subjects(P > 0.05).In the control group there were a higher MMA%( 17.27%,17.06%) lower DMA% (73.89%,72.29%) and lower SMR (81.48%,82.58% ) in those with smoking or drinking/smoking compared with the non-drinking and nonsmoking subjects( 11.52%,79.68% and 87.19%,respectively,all P < 0.05).No significant difference was observed between drinkers and the non-drinking/non-smoking subjects (all P > 0.05).ConclusionThe arsenic methylation capacity of people with drinking and smoking is poorer than that of non-drinking and non-smoking subjects after arsenic exposure.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Endemiology Year: 2012 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Endemiology Year: 2012 Type: Article