Comparison of Alzheimer's disease animal model in BALB/c and Kunming mice by intracerebroventricular injection of β-amyloid / 军事医学科学院院刊
Bulletin of The Academy of Military Medical Sciences
;
(6): 554-557, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-642526
ABSTRACT
Objective:
To compare the Alzheimer's disease model in two species of mice by intracerebroventricular injection of β-amyloid peptide 25-35(Aβ_(25~35)).Method:
The step down test and Morris water-maze were used to investigate the influence of the mice's learning and memorizing ability after intracerebroventricular injection of β-amyloid.Results:
Normal Kunming mice and BALB/c mice had no significant difference in step down test, but the space cognitive ability of Kunming mice was better than that of BALB/c mice. The learning response in step-down test and Morris water-maze is no influence in male, female BALB/c mice and female Kunming mice. Marked differences were observed in male Kunming mice in acquisition, performance and reversal of a place learning response in a Morris water-maze.Conclusion:
The male Kunming mice is much better than female Kunming mice and male, female BALB/c mice in preparing Alzheimer's disease animal model by intracerebroventricular injection of Aβ_(25~35), and is the most suitable animal in this experiment.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Bulletin of The Academy of Military Medical Sciences
Year:
2009
Type:
Article
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